Hosts paintings from the 13th to 18th centuries, including major works by Simone Martini, Raphael, Titian, Caravaggio, Masaccio, Sandro Botticelli, Lorenzo Lotto, Giovanni Bellini, Giorgio Vasari, El Greco, Jacob Philipp Hackert. It also hosts the works of the most important Neapolitan painters, like Jusepe de Ribera, Luca Giordano, the Neapolitan Caravaggisti.