Important as a port, São Tomé is located on Ana Chaves Bay in the northeast of São Tomé Island, and Ilhéu das Cabras lies nearby offshore. São Tomé is located northeast of Trindade, southeast of Guadalupe and northwest of Santana. It is linked to these towns by a highway which encircles the entire island of São Tomé. It is linked to Cape Verde by a weekly ferry.

Álvaro Caminha founded the colony of São Tomé in 1493. The Portuguese came to São Tomé in search of land to grow sugarcane. The island was uninhabited before the arrival of the Portuguese sometime around 1470. São Tomé, situated about 40 kilometres (25 mi) north of the equator, had a climate wet enough to grow sugarcane in wild abundance. 2,000 Jewish children, eight years old and under, were taken from the Iberian peninsula for work on the sugar plantations. The nearby African Kingdom of Kongo eventually became a source of slave labor as well. São Tomé is centred on a sixteenth-century cathedral, that was largely rebuilt in the 19th century. Another early building is Fort São Sebastião, built in 1566 and now the São Tomé National Museum. On July 9, 1595, a slave revolt led by Rei Amador took control of the capital; they were subjugated the following year. In 1599, the Dutch took the city as well as the islands for two days; they re-occupied it in 1641 for a year. The city served as the capital of the Portuguese colony of São Tomé and Príncipe and, from São Tomé and Príncipe's independence in 1975, as capital of the sovereign nation.

When someday comes you'll need to get in.

When someday comes you'll need to be able to get around.