A local guide is required for visitors entering the park, and guides and porters can be hired in Ranohira. Treks in the park can last from several hours to a week or longer. The park includes several natural swimming pools which are popular among tourists, and are excellent sites to see the Benson's Rock Thrush. The main threat to this park comes from illegal wildfires set in the park. The wildfires limit the extent of forest and maximize grasslands used by cattle.

Botanical inventory of the Isalo region began with collections by Perrier de la Bâthie in 1910. Only 10 of the over 400 species that have been documented in Isalo are non-native species. Most (over 70%) are vascular plants that are endemic to Madagascar. There are 13 species that have been found only in Isalo and another 35 are rare species, known from 2-5 sites. The following table lists the species known only from Isalo NP.

When someday comes you'll need to get in.

When someday comes you'll need to be able to get around.