The park can be divided up to 4 areas, each corresponding to one distinct ecosystem:

• The Serondela area (or Chobe riverfront), situated in the extreme Northeast of the park, has as its main geographical features lush floodplains and dense woodland of mahogany, teak and other hardwoods now largely reduced by heavy elephant pressure. The Chobe River, which flows along the Northeast border of the park, is a major watering spot, especially in the dry season (May through October) for large breeding herds of elephants, as well as families of giraffe, sable and cape African Buffalo. The flood plains are the only place in Botswana where the puku antelope can be seen. Birding is also available. Large numbers of carmine bee eaters are spotted in season. When in flood spoonbills, ibis, various species of storks, ducks and other waterfowl flock to the area. This is likely Chobe's most visited section, in large part because of its proximity to the Victoria Falls. The town of Kasane, situated just downstream, is the most important town of the region and serves as the northern entrance to the park.
• The Savuti Marsh area, 10,878 km² (4,200 sq mi) large, constitutes the western stretch of the park (50 km (31 mi) north of Mababe Gate). The Savuti Marsh is the relic of a large inland lake whose water supply was cut a long time ago by tectonic movements. Nowadays the marsh is fed by the erratic Savuti Channel, which dries up for long periods then curiously flows again, a consequence of tectonic activity in the area. It is currently flowing again and in January 2010 reached Savuti Marsh for the first time since 1982. As a result of this variable flow, there are hundred of dead trees along the channel's bank. The region is also covered with extensive savannahs and rolling grasslands, which makes wildlife particularly dynamic in this section of the park. During dry seasons, tourists going on safari often sight rhinoceros, common warthog, kudu, impala, zebra, wildebeest and herds of African bush elephant. During rain seasons, the rich birdlife of the park, 450 species in the whole park, is well represented. Prides of lions, hyenas, zebras or more rarely cheetahs are sighted as well. This region is reputed for its annual migration of zebras and predators.^{[citation needed]}
• The Linyanti Marsh, located at the northwest corner of the park and to the north of Savuti, is adjacent to the Linyanti River. To the west of this area lies Selinda Reserve and on the northern bank of Kwando River is Namibia's Nkasa Rupara National Park. Around these two rivers are riverine woodlands, open woodlands as well as lagoons, and the rest of the region mainly consists of flood plains. There are large concentrations of lion prides, African leopard, African wild dog, roan antelope, sable antelope, a hippopotamus pod and herds of African bush elephant. The rarer red lechwe, sitatunga and a bask of Nile crocodiles also occur in the area. Bird diversity is rich.
• Between Linyanti and Savuti Marshes lies a hot and dry hinterland, mainly occupied by the Nogatsaa grass woodland. This section is little known and is a great place for spotting elands.

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  Lions devouring their killing
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  Hippopotamus
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  Jackal pup
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  Southern African cheetah
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  Cuando River
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  Common warthogs (Phacochoerus africanus) in the banks of the Chobe River.

The original inhabitants of this area were the San bushmen (also known as the Basarwa people in Botswana). They were nomadic hunter-gatherers who were constantly moving from place to place to find food sources, namely fruits, water and wild animals. Nowadays one can find San paintings inside rocky hills of the park.

When someday comes you'll need to get in.

When someday comes you'll need to be able to get around.